Home Urology / Nephrology NLR May Predict Intravesical Prostatic Protrusion in BPH

NLR May Predict Intravesical Prostatic Protrusion in BPH

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Neutrophil-to-lymphocyte
ratio (NLR) may be useful as a surrogate marker of intravesical prostatic
protrusion (IPP) in men with benign prostatic hyperplasia, according to a new
report.

IPP
is an anatomical feature caused by the growth of prostatic lateral and median lobes.

The
new finding is from a study of 250 men older than 50 years who presented with
lower urinary tract symptoms. Investigators found that NLR correlated
positively with IPP and independently predicts IPP of 10 mm or greater.

Among
men with a total prostate volume (TPV) smaller than 40 cm3, mean NLR
was 2.50 in those with IPP 10 mm or greater and 1.71 in those with IPP less
than 10 mm, Mun Su Chung, MD, of Catholic Kwandong University in Incheon South
Korea, reported in Lower Urinary Tract
Symptoms
. NLR differed significantly between men with a prostate smaller
than 40 cm3 and IPP 10 mm or larger and those with a larger prostate
and IPP less than 10 mm (2.50 vs 2.07, respectively).

The
mean NLR was significantly greater among men with IPP 10 mm or larger than in
those with a smaller IPP (2.60 vs 1.90).

“In
conclusion, our analysis demonstrated that NLR can be used as a surrogate
marker for presence of a specific morphological change, IPP,” the authors wrote.
“The clinical value of NLR would be especially important in men with a small
prostate gland but high IPP. The NLR was more strongly correlated with IPP than
with TPV.”

The
authors noted that NLR has been proposed as a surrogate marker for various
conditions, including biochemical failure in prostate cancer, cancer-specific
survival of patients with metastatic renal cell carcinoma, and spontaneous passage
of ureteral stones.

Reference

Chung
MS, Yang YJ, Lee SH, Yoon BI. Association between the neutrophil-to-lymphocyte
ratio and intravesical prostatic protrusion in men with benign prostatic
hyperplasia [published online September 15, 2019]. Low Urin Tract Symptoms. doi:
10.1111/luts.12287

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