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Effects of Concurrent Omega-3 and Cranberry Juice Consumption Along wi

Ahmad Zare Javid,1,2 Leila Maghsoumi-Norouzabad,1,2 Hadi Bazyar,1,3 Vahideh Aghamohammadi,4 Pejman Alavinejad5

1Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 3Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 4Department of Nutrition, Khalkhal University of Medical Sciences, Khalkhal, Iran; 5Alimentary Tract Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Correspondence: Vahideh Aghamohammadi
Department of Nutrition, Khalkhal University of Medical Sciences, Khalkhal, Iran
Tel +989143529145

Background: It seems alternative treatments such as antioxidant intervention and anti-inflammatory intervention adjuvant to antibiotic regimens may enhance cancer prevention approaches and decrease adverse side effects related to therapeutic antibiotic regimens. So, we will evaluate the effects of concurrent omega-3 and cranberry juice supplementation along with standard antibiotic therapy on the eradication of Helicobacter pylori, gastrointestinal symptoms, some serum inflammatory and oxidative stress markers in adults with HP infection.
Methods: We will conduct a 4-week double-blinded randomized clinical trial. The subjects will be randomly stratified according to sex and BMI using a permuted block randomization procedure by Random Allocation Software (RAS). They will be assigned to one of the four study groups: (1) cranberry juice fortified with omega-3 Intervention (n=23), (2) cranberry juice intervention group (n=23), (3) placebo beverage fortified with omega-3 intervention group (n=23), and (4) placebo beverage intervention (control group) (n=23). All statistical analyses will be performed using IBM SPSS Statistics software.
Discussion: A combination of alternative therapies may have a synergistic effect compared to a single approach. It could potentially be more effective in promoting the efficacy of standard antibiotic therapy in eradicating HP infection.
Trial Registration: Iranian Registry of Clinical Trials (IRCT20151128025274N3,
Trial Status: This study is in the early stages of sampling.

Keywords: controlled clinical trial, cranberry juice, fatty acids, omega-3, Helicobacter pylori, inflammation mediators, oxidative stress, vaccinium macrocarpon

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