Home Lymphoma Dr. Skarbnik on the Utility of PI3K Inhibitors in Follicular Lymphoma

Dr. Skarbnik on the Utility of PI3K Inhibitors in Follicular Lymphoma

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Alan P. Z. Skarbnik, discusses ongoing research with PI3​K inhibitors in follicular lymphoma. 

Alan P. Z. Skarbnik, MD, a hematologist/oncologist with Novant Health, discusses ongoing research with PI3​K inhibitors in follicular lymphoma. 

Among ongoing research efforts in follicular lymphoma is the development of novel PI3​K inhibitors, says Skarbnik.

To date, 3 PI3​K inhibitors ​are approved for patients with B-cell malignancies, including idelalisib (Zydelig), copanlisib (Aliqopa), and duvelisib (Copiktra)​, Skarbnik explains. 

The safety profiles of these agents ​vary, but common adverse include gastrointestinal toxicity, inflammatory diarrhea, and rash, ​Skarbnik says.

As such, the goal of second-generation PI3​K inhibitors, ​such as duvelisib, is to ​inhibit disease proliferation and ​minimize​immune-related toxicities by targeting the delta and gamma portions of PI3K, Skarbnik concludes. 

https://www.onclive.com/view/dr-skarbnik-on-the-utility-of-pi3k-inhibitors-in-follicular-lymphoma

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